Why Wild Chaga is Medicinally Superior: A Closer Look at Sterol Composition in Inonotus obliquus

Why Wild Chaga is Medicinally Superior: A Closer Look at Sterol Composition in Inonotus obliquus

ByCody McElrea

A recent comparative study highlights a key difference between wild-grown and lab-cultivated Inonotus obliquus (Chaga): the diversity and richness of their sterol profiles. Wild-harvested mycelia were found to contain significantly higher levels of bioactive sterols, such as lanosterol (45.47%) and inotodiol (25.36%), compounds linked to a wide range of health-supportive properties. In contrast, cultivated mycelia…

Unlocking New Medicines from Microbial Diversity

Unlocking New Medicines from Microbial Diversity

ByCody McElrea

Nature remains one of the richest sources of pharmaceuticals, with over 20,000 microbial secondary metabolites identified to date. However, only a fraction of these compounds have made it into drug development pipelines. As synthetic chemical libraries and combinatorial chemistry compete for dominance in drug discovery, natural product research must become more efficient and strategic than…

Turkey Tail Health Benefits

Turkey Tail Health Benefits

ByCody McElrea

Health Benefits References Awadasseid, A., Hou, J., Gamallat, Y., Xueqi, S., Eugene, K. D., Musa Hago, A., Bamba, D., Meyiah, A., Gift, C., & Xin, Y. (2017). Purification, characterization, and antitumor activity of a novel glucan from the fruiting bodies of Coriolus Versicolor. PloS one, 12(2), e0171270. https://doi.org/10.1371/journal.pone.0171270 Bains, A., & Chawla, P. (2020). In…

Inside the Extract: Yield, Ratios, and the Role of Beta Glucans

Inside the Extract: Yield, Ratios, and the Role of Beta Glucans

ByCody McElrea

Best practice: Quantity of genuine extract: ex 80 % DER genuine: 3-6:1 Other Excipients: 20 % Extraction Solvent: Ethanaol 70 % V/V Microencapsulation of Oleoresin (from garlic) using maltodextrin- optimal 10 % garlic 60 % maltodextrin at 200C https://sci-hub.se/10.1016/j.ijbiomac.2014.08.011 Microencapsulation of Anthocyanins (from black glutinous Rice) https://www.mdpi.com/2304-8158/13/9/1326 Starch/Beta Glucans https://www.nammex.com/beta-glucan-breakdown-digesting-the-power-of-mushrooms/ Starch –is a polysaccharide comprising glucose monomers…

Edible Mushrooms Show Promising Antitumor Effects When Taken Orally

Edible Mushrooms Show Promising Antitumor Effects When Taken Orally

ByCody McElrea

A landmark study conducted in Japan explored the antitumor potential of common edible mushrooms, such as Shiitake (Lentinus edodes) and Maitake (Grifola frondosa), when administered orally to tumor-bearing mice. By supplementing standard feed with 10–30% powdered fruiting bodies, researchers observed significant reductions in tumor growth—up to 58.3% with Shiitake and 43.3% with Maitake in mice…

Hoof Conk/Fungus Health Benefits

Hoof Conk/Fungus Health Benefits

ByCody McElrea

Health Benefits References Kalitukha L, Galiano A, Harrison F. Medicinal Potential of the Insoluble Extracted Fibers Isolated from the Fomes fomentarius (Agaricomycetes) Fruiting Bodies: A Review. Int J Med Mushrooms. 2023;25(3):21-35. doi: 10.1615/IntJMedMushrooms.2022047222. PMID: 37017659. Gagwani, D. 2023. Chitin-definition, structure and function. Study.com.https://study.com/academy/lesson/chitin-definition-structure-function.html  Gupta, V. K., Schmoll, M., Maki, M., Tuohy, M., Mazutti, M. A.,…

Lupeol: A Plant-Based Triterpenoid with Therapeutic Promise

Lupeol: A Plant-Based Triterpenoid with Therapeutic Promise

ByCody McElrea

Lupeol is a naturally occurring triterpenoid with the molecular formula C₃₀H₅₀O. It is found in various plants, including fruits and medicinal herbs. Lupeol has been studied for its potential therapeutic properties, including anti-inflammatory, anticancer, and antimicrobial effects. According to PubChem, Lupeol is identified with the DrugBank ID DB12622

Inotodiol from Chaga: A Potent Compound with Antitumor Potential

Inotodiol from Chaga: A Potent Compound with Antitumor Potential

ByCody McElrea

Inonotus obliquus, commonly known as Chaga, is a medicinal mushroom long celebrated for its immune-supporting properties. Recent scientific research has identified a powerful bioactive compound within Chaga—inotodiol, a lanostane-type triterpenoid—with promising antitumor activity. This study investigated the effects of inotodiol on leukemia cells, revealing its ability to inhibit cancer cell proliferation. The findings showed that…

Chaga & Beta Glucan

Chaga & Beta Glucan

ByCody McElrea

For centuries, medicinal mushrooms have been a part of traditional healing systems, especially in East Asian cultures. Modern science is now catching up, with researchers focusing on the anticancer potential of fungal compounds that offer a more targeted, low-toxicity approach compared to conventional chemotherapy. Unlike many first-generation natural drugs, which can harm healthy tissue, compounds…

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